General Information

  • ID:  hor000743
  • Uniprot ID:  P30945
  • Protein name:  Secretoneurin
  • Gene name:  NA
  • Organism:  Pelophylax ridibundus (Marsh frog) (Rana ridibunda)
  • Family:  Chromogranin/secretogranin protein family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Pelophylax (genus), Ranidae (family), Ranoidea (superfamily), Neobatrachia (suborder), Anura (order), Batrachia (superorder), Amphibia (class), Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  GO:0005576 extracellular region; GO:0030141 secretory granule

Sequence Information

  • Sequence:  TNEIVEGQYTPQSLATLQSVFQELGKLKGQANN
  • Length:  33
  • Propeptide:  MSSQRNYCLAGCLSSCILVILMSFSDAASFQYYQVPQQDQEYRMKTLQRLPSPDMLKALEYIENLRKQASRTESLPDYTSYQGAPFLSEQKDTQALSTDTAKSPTSDDESEWMRAMLEALMQAEKEAKVSPQEKNNLYMDKNIPPELIEDYDSNKWSEKRPKAGKFSSRLYDDYSRDNPLKRTNEIVEGQYTPQSLATLQSVFQELGKLKGQANNKRDRMEEDQKLYKDDEDDLYKANNIAYEDVAGGEDWNPIEEKVESQTQEELKESKEEVEKTDDMEDEIKRSGLLGLQDEEPEKDTKEQESENLSNLMNTYLNMWMNRMDKGKQNPDRRSLRFSGKELDPEAIYQLIDISRNLQIPPEDLIDMLRDEDGRKFGGRLESEKEVDVPLDLDEVTETMTDKTNVYKNKQGFVRQPTSPVLPNIPEGLTVEDMVNLMGADKLQNRFKQNNGLQRPYPMLSKIKGHKAIWPKESEKRQIEYESRPEKEEELADYVVKMLAKYPELLGNNQNKKMPIPYSAGDLQELEKQYENALRGYVNMRGYQDLETVSSSNRRLSTRENDDTQNKQYIDEDLLMKVLEYLNQEKAEKARDHSVKRSMENM
  • Signal peptide:  MSSQRNYCLAGCLSSCILVILMSFSDAASF
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  May be important in regulation of neurosecretion.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P30945-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor000743_AF2.pdbhor000743_ESM.pdb

Physical Information

Mass: 417796 Formula: C157H253N43O54
Absent amino acids: CDHMRW Common amino acids: Q
pI: 4.48 Basic residues: 2
Polar residues: 12 Hydrophobic residues: 10
Hydrophobicity: -59.39 Boman Index: -5170
Half-Life: 7.2 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 82.73
Instability Index: 4143.94 Extinction Coefficient cystines: 1490
Absorbance 280nm: 46.56

Literature

  • PubMed ID:  2060624
  • Title:  Identification of a Peptide Arising From the Specific Post-Translation Processing of Secretogranin II